Tuesday, May 28, 2019
5:15 p.m. — room Jaures (29 rue d’Ulm)
Cells’ plasma membrane is a highly deformable material : it is strongly curved during cell migration upon the formation of cellular protrusions, or during endo/exocytosis where small buds form and eventually detach from the membrane. These membrane-shaping processes always require the interaction with proteins (for instance proteins with an intrinsically curved shape, or proteins that insert into the lipid bilayer) and in some cases with the actin cytoskeleton. Over the years, in vitro reconstituted membrane systems combined to theoretical models have been instrumental for understanding how proteins and cytoskeleton shape cellular membranes. I will present examples from my group that illustrate how, with these model membranes, we have deciphered some mechanisms underlying endocytosis as well as the generation of protrusions.